Caspases: potential targets for regulating cell death
نویسندگان
چکیده
منابع مشابه
Death without caspases, caspases without death.
Apoptosis is a conserved cell-death process displaying characteristic morphological and molecular changes including activation of caspase proteases. Recent work challenges the accepted roles of these proteases. New investigations in mice and the nematode Caenorhabditis elegans suggest that there could be caspase-independent pathways leading to cell death. In addition, another type of cell death...
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Programmed cell death (PCD) is the genetically controlled suicide of cells. The tight regulation of this program is essential to ensure that it is only activated in the required cells at the proper moment. Deregulation of apoptosis, the main form of PCD in animals, is associated with diseases such as cancer, autoimmune diseases, and neurodegenerative disorders (Shi, 2002). In plants, deregulati...
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Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made to further understand caspase structure and function, providing a unique basis for drug design. This Review gives an overview of caspases and their classification, structure, and substrate specificity. We also describe the current knowledge of how interference with ca...
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Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, a...
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Upon viral infection, cells commit suicide and die by Successful implosion of a building depends on the preapoptosis as an altruistic defense mechanism to benefit cise and timely detonation of explosives. If a cell underthe organism. Several viruses have built into their gegoing apoptosis is analogous to an imploding building, nome apoptosis-inhibiting arsenal, including proteins then the explo...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2004
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2004.tb00468.x